Multiple Expression of Ly-6C and Accumulation of a Ly-6C Pre-mRNA in Activated Macrophages Involved in Rejection of an Allografted Tumor

Multiple expression of Ly-6C and accumulation of a Ly-6C pre-mRNA in activated macrophages involved in rejection of an allografted tumor.

We established a monoclonal antibody against a surface antigen of activated macrophages (Møs) involved in the rejection of an allografted mouse tumor, Meth A. Bacteria-elicited Møs also expressed the antigen but resident or inflammatory Møs, or other leukocytes, did not. The antigen was identified as Ly-6C by isolation of cDNA clones encoding it. Two-dimensional immunoblotting revealed that Ly-...

Plasticity of Ly-6C Myeloid Cells in T Cell Regulation

CD11b + Ly-6C hi cells, including inflammatory monocytes (IMCs) and inflammatory dendritic cells (IDCs), are important in infectious , autoimmune, and tumor models. However, their role in T cell regulation is controversial. In this article, we show that T cell regulation by IMCs and IDCs is determined by their activation state and is plastic during an immune response. Non-activated IMCs and IDC...

Expressed by B Lymphocytes and Ly-6i Recognize Two Potential Ligands Ly-6 Superfamily Members Ly-6a/e, Ly-6c

CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis.

Innate immune cells may regulate adaptive immunity by balancing different lineages of T cells and providing negative costimulation. In addition, CD11b(+)Gr-1(+) myeloid-derived suppressor cells have been described in tumor, parasite infection, and severe trauma models. In this study, we observe that splenic CD11b(+) cells markedly increase after experimental autoimmune encephalomyelitis (EAE) i...

CD11b Ly-6C Suppressive Monocytes in Experimental Autoimmune Encephalomyelitis